Overexpression of the Na-K-ATPase 2-subunit improves lung liquid clearance during ventilation-induced lung injury
نویسندگان
چکیده
Yochai Adir, Lynn C. Welch, Vidas Dumasius, Phillip Factor, Jacob I. Sznajder, and Karen M. Ridge Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Division of Pulmonary Medicine, Carmel Medical Center, Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York; and Jesse Brown Veterans Administration Medical Center-Lakeside Division, Chicago, Illinois
منابع مشابه
Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
Mechanical ventilation with high tidal volumes (HV(T)) impairs lung liquid clearance (LLC) and downregulates alveolar epithelial Na-K-ATPase. We have previously reported that the Na-K-ATPase alpha(2)-subunit contributes to LLC in normal rat lungs. Here we tested whether overexpression of Na-K-ATPase alpha(2)-subunit in the alveolar epithelium would increase clearance in a HV(T) model of lung in...
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متن کاملAlveolar Type 1 Cells Express the 2 Na,K-ATPase, Which Contributes to Lung Liquid Clearance
The alveolar epithelium is composed of alveolar type 1 (AT1) and alveolar type 2 (AT2) cells, which represent 95% and 5% of the alveolar surface area, respectively. Lung liquid clearance is driven by the osmotic gradient generated by the Na,K-ATPase. AT2 cells have been shown to express the 1 Na,K-ATPase. We postulated that AT1 cells, because of their larger surface area, should be important in...
متن کاملAlveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.
The alveolar epithelium is composed of alveolar type 1 (AT1) and alveolar type 2 (AT2) cells, which represent approximately 95% and approximately 5% of the alveolar surface area, respectively. Lung liquid clearance is driven by the osmotic gradient generated by the Na,K-ATPase. AT2 cells have been shown to express the alpha1 Na,K-ATPase. We postulated that AT1 cells, because of their larger sur...
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